Saturday July 25, 2009

Q; What is the approximate half life of infusing epinephrine in septic shock patient?


Answer: About 3.5 minutes

Also, note that - Epinephrine pharmacokinetics is linear in septic shock patients, without any saturation at high doses. Basal neurohormonal status does not influence epinephrine pharmacokinetics.



Reference: Click to get abstract

Pharmacokinetics of epinephrine in patients with septic shock: modelization and interaction with endogenous neurohormonal status - Published july 21, 2009 - Critical Care 2009, 13:R120